Conexeu Sciences Sees a New Category Forming in Medical Aesthetics as Research Turns to Regeneration

Peer-reviewed research points to the extracellular matrix, the framework that holds tissue together, as central to that work. More than a decade of research has gone into Conexeu’s CXU™ Platform

Highlights

• Regenerative aesthetics has become a $1.6 billion market of its own, and analysts see double-digit growth ahead.¹^, ²
• Medical research confirms it: regeneration is what leads the next category, not appearance.³^, ⁴
• Conexeu began developing its technology twelve years ago, before regeneration had a name in aesthetics.⁵
  
  

RENO, Nev., Aug. 18, 2026 (GLOBE NEWSWIRE) -- Conexeu Sciences Inc. (Nasdaq: CNXU) (“Conexeu” or the “Company”), a preclinical-stage biotechnology company advancing an investigational tissue-restoration platform, believes a new category is emerging within medical aesthetics centered on regenerative tissue restoration. Rather than focusing solely on replacing lost volume, this developing area of medicine is increasingly exploring approaches aimed at restoring, rebuilding, enhancing, and contouring soft tissue. Conexeu believes the opportunity spans facial rejuvenation, age-related tissue changes, post-weight-loss restoration, soft-tissue enhancement, and body contouring, areas where patients increasingly seek natural-looking outcomes supported by biological restoration.

Aesthetic treatments have long focused on replacing lost volume, reshaping tissue, and addressing visible signs of aging. Regenerative medicine is bringing greater attention to the underlying tissue and the biological environment that supports it. Aging and significant weight loss can alter soft-tissue volume, structure, and quality in the face and the body.

Recent academic research points in the same direction. A 2026 review in JAAD Reviews examines regenerative medicine across aesthetic, medical and surgical dermatology, including tissue engineering, biomaterials and extracellular matrix (ECM)-based approaches. The authors discuss the ECM as providing structural and biochemical cues involved in cellular activity and tissue repair.

A 2025 review in the Journal of Clinical Medicine brings that discussion directly into aesthetic medicine. The authors describe a shift toward regenerative science and identify ECM-based approaches alongside exosomes, platelet-rich plasma, and adipose-derived stem cells among the technologies being studied. The review discusses potential applications for ECM-based scaffolds in skin rejuvenation, wound healing, and scar remodeling.

Together, the reviews reflect growing scientific interest in approaches that look past appearance to the tissue underneath it. The ECM is the framework that holds tissue together. Collagen, elastin, and glycosaminoglycans are individual components of that larger matrix.

Independent market research points the same way. Analysts now track bioregenerative aesthetics as its own market segment, sized at roughly $1.6 billion in 2025 and projected to grow at more than 11 percent annually through 2034¹. The broader regenerative aesthetics market was estimated at $15.6 billion² in 2025.

The scientific interest comes amid strong demand for non-surgical aesthetics. More than 20.5 million non-surgical aesthetic procedures were performed worldwide in 2024, according to the International Society of Aesthetic Plastic Surgery.

“What is encouraging is the growing academic attention being paid to the extracellular matrix and its role in tissue structure, remodeling, and regeneration,” said Miles Harrison, President and CEO of Conexeu. “This is the scientific foundation of our CXU™ platform and an area our medical device has been undergoing research for more than a decade. As the field evolves, we remain focused on building the evidence needed to determine whether an ECM-based approach can expand how physicians think about soft-tissue restoration.”

Conexeu ECM-based biomaterial scaffold CXU ^TM is designed as a structural support of native extracellular matrix, which can be thought of as the natural framework that gives tissue its structure and provides the environment around cells. As scientific understanding of tissue remodeling continues to evolve, Conexeu believes the extracellular matrix may represent an important area for future investigation within medical aesthetics.

CXU is designed as a multi-component collagen-ECM scaffold rather than a single-component material. Native extracellular matrix includes collagen, elastin, and glycosaminoglycans among its structural components. Rather than focusing on one matrix component alone, CXU is designed around a broader matrix framework incorporating multiple ECM-derived structural components. Conexeu believes this broader extracellular matrix approach warrants further evaluation for applications involving soft tissue restoration and regenerative medicine.

Conexeu is now building the evidence behind that approach. The Company recently completed the 12-month P.R.O.O.F. (Performance and Regeneration Outcomes of Flowable Collagen) phase of its CXU preclinical program. The study met its predefined objectives in a small-volume facial tissue model and in a large-volume subcutaneous tissue model evaluated at approximately 200cc-equivalent volume. These preclinical study volumes do not establish appropriate or safe dosing levels in humans. Detailed 12-month findings, quantitative analyses, and individual histologic endpoints are being reserved for scientific presentation and peer-reviewed publication.

About Conexeu Sciences Inc.

Architecting Bioregeneration™. Conexeu Sciences is a preclinical-stage regenerative tissue platform company. Our patented extracellular matrix (ECM) platform, CXU™, is built on a single structural principle and is designed to support bioregeneration: one formula, one device, designed to scale across multiple addressable markets.

Conexeu is targeting large, multi-billion-dollar end markets, including wound care, periodontal applications, and facial and body tissue restoration, including the tissue changes that can follow GLP-1 weight loss, with further expansion opportunities in 3D printing and biofabrication workflows and the veterinary market. The Company is advancing a predicate-based U.S. regulatory strategy with an anticipated 510(k) submission in early 2027 for its initial indication, subject to regulatory review.

Conexeu is led by an experienced leadership team with deep expertise in biomaterials, regenerative medicine, and medical device commercialization and development.

About CXU™

CXU™ is designed to support soft tissue lost through injury, aging, and the tissue changes that can follow GLP-1 weight loss. The Company's lead device candidate, Ten-Minute Tissue™, is a thermosensitive extracellular matrix (ECM) that remains fluid at room temperature and is designed to transition to a stable gel in situ at body temperature within approximately ten minutes. In preclinical research, Ten-Minute Tissue™ has been characterized for host cell infiltration, vascular ingrowth, organized remodeling, and a low-inflammatory profile, conditions intended to support constructive remodeling.²

The platform is grounded in more than a decade of university preclinical research and protected by a multi-jurisdictional patent estate spanning more than 40 jurisdictions (U.S., EU, Japan, and Australia, with protection pending in Canada). Conexeu owns the platform IP, holding all rights, title, and interest, with no royalty or licensing obligations, and intends to expand across new indications and markets.

Sources

1. Polaris Market Research, Bioregenerative Aesthetic Injectables Market Share, Size, Trends, Industry Analysis Report, 2026–2034. Global market estimated at approximately $1.6 billion in 2025, projected CAGR of 11.3% over the forecast period.
2. The Business Research Company, Regenerative Aesthetics Global Market Report 2026. Market estimated at $15.58 billion in 2025, growing to $17.66 billion in 2026 at a 13.4% growth rate, with a projected $28.88 billion by 2030.
3. JAAD Reviews, Regenerative medicine in dermatology, 2026.
4. Journal of Clinical Medicine, Harnessing Regenerative Science in Aesthetic Surgery: The Biologically Driven Future, 2025.
5. Conexeu Sciences Inc. development path, Form S-1/A, as filed with the U.S. Securities and Exchange Commission.
   

Media Contact
Gateway Group
CNXU@Gateway-grp.com
949.574.3860

Safe Harbor Statement

Except for the statements of historical fact contained herein, the information presented in this news release constitutes "forward-looking statements" as such term is used in applicable United States securities laws. These statements relate to analysis and other information that are based on forecasts or future results, estimates of amounts not yet determinable, and assumptions of management, including, but not limited to, statements regarding regulatory pathway, submission timing, category development and platform expansion. Any other statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, objectives, assumptions or future events or performance (often, but not always, using words or phrases such as "expects", or "does not expect", "is expected", "anticipates" or "does not anticipate", "plans", "estimates" or "intends", or stating that certain actions, events or results "may", "could", "would", "might" or "will" be taken, occur or be achieved) are not statements of historical fact and should be viewed as "forward-looking statements". We have based these forward-looking statements on our current expectations about future events or performance. While we believe these expectations are reasonable, such forward-looking statements are inherently subject to risks and uncertainties, many of which are beyond our control. Our actual future results may differ materially from those discussed or implied in our forward-looking statements for various reasons. Factors that could contribute to such differences include, but are not limited to: international, national and local general economic and market conditions; demographic changes; the early-stage, preclinical nature of the Company's device candidates, including B.R.E.A.S.T.™ and Ten Minute Tissue™, and the inherent uncertainty of preclinical and clinical development, including the possibility that preclinical results may not be predictive of clinical outcomes; preclinical study objectives described as met may not result in clinical benefit, regulatory clearance, or commercial success; third party market estimates disclosed herein, including GLP-1, aesthetics and injectable market figures may prove inaccurate or may not reflect the Company’s addressable market; the investigational status of CXU™, which is not cleared or approved for marketing in any jurisdiction, and that no assurance can be given that any such clearance or approval will be obtained; risks associated with the Company's planned 510(k) submission, including the possibility that the submission may not be completed within the anticipated first-quarter 2027 timeframe or at all; the risk that the FDA may not accept the 510(k) submission as filed, may request additional information, data, or testing, or may determine that the device is not substantially equivalent to the identified predicate device; the risk that marketing clearance for the CXU™ wound-care device may not be obtained, may be delayed, or may be subject to conditions or limitations that affect the Company's commercial plans; changes in FDA regulatory policy, guidance, or review standards applicable to 510(k) submissions or the Company's identified predicate devices; the ability of the Company to sustain, manage or forecast its growth; the ability of the company to develop and commercialize its products; the ability of the Company to raise capital to complete its plans and fund its operations; the commercial viability of the contemplated processing plant; the continued availability of key leadership personnel; adverse publicity; competition and changes in the advanced wound care market, medical aesthetics market and tissue engineering and reconstruction; fluctuations and difficulty in forecasting operating results; business disruptions, such as technological failures and/or cybersecurity breaches. There can be no assurance that such statements will prove to be accurate as actual results, and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements contained in this news release and in any document referred to in this news release. The forward-looking statements included in this release are made only as of the date hereof. For forward-looking statements in this news release, the Company claims the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. The Company assumes no obligation to update or supplement any forward-looking statements whether as a result of new information, future events or otherwise. This news release shall not constitute an offer to sell or the solicitation of any offer to buy our securities.